Reaction: PPO oxidises PPGEN9 to PRIN9
- in pathway: Heme biosynthesis
Six electrons are oxidized in protophorphyrinogen IX (PPGEN9) to form the planar macrocycle protoporphyrin IX (PRIN9). This reaction is performed by the enzyme protoporphyrinogen oxidase (PPO). PPO functions as a homodimer containing one non-covalently-bound FAD. The protein resides on the outer surface of the inner mitochondrial membrane. PPO deficiency is associated with variegate porphyria in vivo.
Reaction - small molecule participants:
H2O2 [mitochondrial intermembrane space]
PRIN9 [mitochondrial intermembrane space]
O2 [mitochondrial intermembrane space]
PPGEN9 [mitochondrial intermembrane space]
Reactome.org reaction link: R-HSA-189423
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Reaction input - small molecules:
dioxygen
protoporphyrinogen
Reaction output - small molecules:
hydrogen peroxide
protoporphyrin
Reactome.org link: R-HSA-189423