Reaction: ALAD binds to Pb2+
- in pathway: Heme biosynthesis
Lead binds to ALAD enzyme displacing half the zinc ions essential for its catalytic activity and inactivating it. Lead is a major environmental toxin and this enzyme is one of its principal molecular targets (Jaffe et al. 2001).
Reaction - small molecule participants:
Zn2+ [cytosol]
Pb2+ [cytosol]
Reactome.org reaction link: R-HSA-190141
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Reaction input - small molecules:
lead(0)
Reaction output - small molecules:
zinc(2+)
Reactome.org link: R-HSA-190141