Reaction: UROD decarboxylates URO1 to COPRO1
- in pathway: Heme biosynthesis
Cytosolic uroporphyrinogen decarboxylase (UROD) catalyzes the sequential removal of four carboxylic groups from the acetic acid side chains of uroporphyrinogen I (URO1) to form coproporphyrinogen I (COPRO1). UROD catalyzes this reaction less efficiently than the decarboxylation of uroporphyrinogen III (de Verneuil et al. 1983).
Reaction - small molecule participants:
CO2 [cytosol]
COPRO1 [cytosol]
URO1 [cytosol]
Reactome.org reaction link: R-HSA-190182
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Reaction input - small molecules:
uroporphyrinogen I(8-)
Reaction output - small molecules:
carbon dioxide
coproporphyrinogen I(4-)
Reactome.org link: R-HSA-190182