Reaction: Galactosylation of Pre-NOTCH
- in pathway: Pre-NOTCH Processing in Golgi
Beta-1,4-galactosyltransferase 1 (B4GALT1) is a Golgi membrane enzyme responsible for galactosylation of N-acetylglucosaminyl group added by fringe enzymes to O-linked fucosyl residues on NOTCH. This results in formation of trisaccharide chains on NOTCH (Gal-beta1,4-GlcNAc-beta1,3-fucitol), and is a necessary step for fringe-mediated modulation of NOTCH signaling.
Reaction - small molecule participants:
UDP [Golgi lumen]
UDP-Gal [Golgi lumen]
Reactome.org reaction link: R-HSA-1912352
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Reaction input - small molecules:
UDP-alpha-D-galactose(2-)
Reaction output - small molecules:
UDP(3-)
Reactome.org link: R-HSA-1912352