Reaction: Sialylation of Pre-NOTCH
- in pathway: Pre-NOTCH Processing in Golgi
Mature fringe-modified NOTCH usually has a tetrasaccharide attached to conserved fucosylated serine and threonine residues in EGF repeats. The chemical structure of these tetrasaccharides is Sia-alpha2,3-Gal-beta1,4-GlcNAc-beta1,3-fucitol (Moloney et al. 2000). The identity of sialyltransferase(s) that add sialic acid to galactose remains unknown in this context. Based on the type of chemical bonds in the tetrasaccharide, there are three known Golgi membrane sialyltransferases that could perform this function: ST3GAL3, ST3GAL4, ST3GAL6 (Harduin-Lepers et al. 2001).
Reaction - small molecule participants:
CMP [Golgi lumen]
CMP-Neu5Ac [Golgi lumen]
Reactome.org reaction link: R-HSA-1912378
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Reaction input - small molecules:
CMP-N-acetyl-beta-neuraminate(2-)
Reaction output - small molecules:
cytidine 5'-monophosphate(2-)
Reactome.org link: R-HSA-1912378