Reaction: FDPS dimer transfers IPPP to DMAPP
- in pathway: Cholesterol biosynthesis
The family of enzymes called prenyltransferases is involved in the biosynthesis of isoprenoids. Two members of this family are known to catalyse the sequential condensation of isopentenyl pyrophosphate (IPPP) to DMAPP: farnesyl pyrophosphate synthase dimer (FPPS dimer) and geranylgeranyl pyrophosphate synthetase hexamer (GGPPS hexamer) (Kavanaugh et al, 2006). Both enzymes utlise Mg2+ as cofactor (Chang et al. 2021).
Reaction - small molecule participants:
PPi [cytosol]
GPP [cytosol]
DMAPP [cytosol]
IPPP [cytosol]
Reactome.org reaction link: R-HSA-191322
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Reaction input - small molecules:
prenyl diphosphate
isopentenyl diphosphate
Reaction output - small molecules:
diphosphate(3-)
geranyl diphosphate
Reactome.org link: R-HSA-191322