Reaction: HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA
- in pathway: Cholesterol biosynthesis
3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMG-CoA synthase) catalyzes the condensation of acetyl CoA with acetoacetyl CoA to produce HMG-CoA. There are two forms of this enzyme, cytosolic and mitochondrial. The cytosolic form is ubiquitous in the body and is involved in cholesterol biosynthesis and synthesis of other isoprenoid products. The mitochondrial form, found solely in the liver and kidney, is involved in the ketogenic pathway.
Reaction - small molecule participants:
bHMG-CoA [cytosol]
H+ [cytosol]
CoA-SH [cytosol]
ACA-CoA [cytosol]
H2O [cytosol]
Ac-CoA [cytosol]
Reactome.org reaction link: R-HSA-191323
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Reaction input - small molecules:
acetoacetyl-CoA(4-)
water
acetyl-CoA(4-)
Reaction output - small molecules:
(3S)-3-hydroxy-3-methylglutaryl-CoA(5-)
hydron
coenzyme A(4-)
Reactome.org link: R-HSA-191323