Reaction: Squalene 2,3-epoxide cyclizes, forming lanosterol
- in pathway: Cholesterol biosynthesis
Lanosterol synthase (LSS) catalyzes the cyclization of squalene 2,3-epoxide to lanosterol, a reaction that forms the sterol nucleus. LSS is located on the ER membrane and is active in monomeric form (Ruf et al. 2004).
Reaction - small molecule participants:
LAN [endoplasmic reticulum membrane]
SQOX [cytosol]
Reactome.org reaction link: R-HSA-191366
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Reaction input - small molecules:
(S)-2,3-epoxysqualene
Reaction output - small molecules:
lanosterol
Reactome.org link: R-HSA-191366