Reaction: Two FPP molecules dimerize to form presqualene diphosphate
- in pathway: Cholesterol biosynthesis
Farnesyl diphosphate farnesyltransferase (FDFT; squalene synthase) catalyzes the reductive dimerization of two farnesyl diphosphate (FPP) molecules to form squalene. This happens in two distinct steps. The first step of dimerization forms presqualene diphosphate (Pandit et al. 2000).
Reaction - small molecule participants:
PPi [cytosol]
PSQPP [cytosol]
FAPP [cytosol]
Reactome.org reaction link: R-HSA-191405
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Reaction input - small molecules:
2-trans,6-trans-farnesyl diphosphate
Reaction output - small molecules:
diphosphate(3-)
presqualene diphosphate
Reactome.org link: R-HSA-191405