Reaction: 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
7alpha-hydroxycholesterol and NAD+ react to form 4-cholesten-7alpha-ol-3-one, NADH, and H+, in a reaction catalyzed by HSD3B7 (3 beta-hydroxysteroid dehydrogenase type 7) in the endoplasmic reticulum membrane. Its function in vivo has been confirmed in studies of patients with defects in bile acid synthesis (Schwarz et al. 2000).
Reaction - small molecule participants:
H+ [cytosol]
4CHOL7aOLONE [endoplasmic reticulum membrane]
NADH [cytosol]
NAD+ [cytosol]
7 alpha-hydroxycholesterol [endoplasmic reticulum membrane]
Reactome.org reaction link: R-HSA-192097
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Reaction input - small molecules:
NAD(1-)
7alpha-hydroxycholesterol
Reaction output - small molecules:
hydron
7alpha-hydroxycholest-4-en-3-one
NADH(2-)
Reactome.org link: R-HSA-192097