Reaction: 5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol
5Beta-cholesten-7alpha-ol-3-one and NADPH + H+ form 5beta-cholestan-3alpha,7alpha-diol and NAPDP+. The reaction is catalyzed by 3alpha-hydroxysteroid dehydrogenase (AKR1C4), a cytosolic enzyme belonging to the aldo-keto reductase family (Dufort et al. 2001). Biochemical studies with rat proteins raise the possibility that other related enzymes may also carry out this reaction in vivo (Russell 2003).
Reaction - small molecule participants:
5beta-cholestan-3alpha,7alpha-diol [cytosol]
NADP+ [cytosol]
5beta-cholestan-7alpha-ol-3-one [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-192160
======
Reaction input - small molecules:
7alpha-hydroxy-5beta-cholestan-3-one
hydron
NADPH(4-)
Reaction output - small molecules:
5beta-cholestane-3alpha,7alpha-diol
NADP(3-)
Reactome.org link: R-HSA-192160