Reaction: CYP39A1 7-hydroxylates 24OH-CHOL
- in pathway: Endogenous sterols
24-hydroxycholesterol 7-alpha-hydroxylase (CYP39A1), located on the ER membrane, 7-alpha-hydroxylates 24-hydroxycholesterol (24OH-CHOL) to cholest-5-ene-3beta,7alpha,24-triol (CHOL7a,24(S)DIOL). In the body, expression of CYP39A1 is restricted to the liver and is involved in bile acid metabolism (Li-Hawkins et al. 2000).
Reaction - small molecule participants:
CHOL7a,24(S)DIOL [endoplasmic reticulum membrane]
H2O [cytosol]
NADP+ [cytosol]
24OH-CHOL [endoplasmic reticulum membrane]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
CHOL7a,24(S)DIOL [endoplasmic reticulum membrane]
H2O [cytosol]
NADP+ [cytosol]
24OH-CHOL [endoplasmic reticulum membrane]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-192178
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Reaction input - small molecules:
(24S)-24-hydroxycholesterol
hydron
dioxygen
NADPH(4-)
(24S)-24-hydroxycholesterol
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
(24S)-7alpha,24-dihydroxycholesterol
water
NADP(3-)
(24S)-7alpha,24-dihydroxycholesterol
water
NADP(3-)
Reactome.org link: R-HSA-192178