Reaction: Thiolysis of 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA yields choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA and CoASH react to form choloyl-CoA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-one-CoA) and propionyl CoA. This reaction, in the peroxisomal matrix, is catalyzed by peroxisomal thiolase 2 (sterol carrier protein 2).
Reaction - small molecule participants:
propionyl CoA [peroxisomal matrix]
choloyl-CoA [peroxisomal matrix]
CoA-SH [peroxisomal matrix]
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA [peroxisomal matrix]
Reactome.org reaction link: R-HSA-192341
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Reaction input - small molecules:
coenzyme A(4-)
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA
Reaction output - small molecules:
propionyl-CoA
choloyl-CoA(4-)
Reactome.org link: R-HSA-192341