Reaction: CYP19A1 hydroxylates ANDST to E1
- in pathway: Estrogen biosynthesis
The conversion of androstenedione (ANDST) to estrone (E1) is catalysed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane (Toda et al. 1990, Simpson et al. 1994).
Reaction - small molecule participants:
H2O [cytosol]
E1 [cytosol]
NADP+ [cytosol]
HCOOH [cytosol]
H+ [cytosol]
O2 [cytosol]
ANDST [cytosol]
NADPH [cytosol]
H2O [cytosol]
E1 [cytosol]
NADP+ [cytosol]
HCOOH [cytosol]
H+ [cytosol]
O2 [cytosol]
ANDST [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193060
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Reaction input - small molecules:
hydron
dioxygen
androst-4-ene-3,17-dione
NADPH(4-)
hydron
dioxygen
androst-4-ene-3,17-dione
NADPH(4-)
Reaction output - small molecules:
water
estrone
NADP(3-)
formate
water
estrone
NADP(3-)
formate
Reactome.org link: R-HSA-193060