Reaction: CYP17A1 17-hydroxylates PREG
- in pathway: Glucocorticoid biosynthesis
Pregnenolone (PREG) and NADPH + H+ react to form 17alpha-hydroxypregnenolone (17aHPREG), NADP+, and H2O. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), associated with the endoplasmic reticulum membrane, catalyzes this reaction.
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
17aHPREG [cytosol]
PREG [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
H2O [cytosol]
NADP+ [cytosol]
17aHPREG [cytosol]
PREG [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193068
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Reaction input - small molecules:
pregnenolone
hydron
dioxygen
NADPH(4-)
pregnenolone
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
17alpha-hydroxypregnenolone
water
NADP(3-)
17alpha-hydroxypregnenolone
Reactome.org link: R-HSA-193068