Reaction: CYP17A1 cleaves 17aHPROG to ANDST
- in pathway: Androgen biosynthesis
17Alpha-hydroxyprogesterone (17aHPROG), NADPH + H+, and O2 react to form 4-Androstene-3, 17-dione (ANDST), NADP+, H2O, and acetaldehyde. Steroid 17 alpha hydroxylase/17,20 lyase (CYP17A1), which also catalyzes 17-alpha-hydroxylation, catalyzes this lyase reaction.
Reaction - small molecule participants:
H2O [cytosol]
CH3CHO [cytosol]
NADP+ [cytosol]
ANDST [cytosol]
H+ [cytosol]
O2 [cytosol]
17aHPROG [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193099
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Reaction input - small molecules:
hydron
dioxygen
17alpha-hydroxyprogesterone
NADPH(4-)
Reaction output - small molecules:
water
acetaldehyde
NADP(3-)
androst-4-ene-3,17-dione
Reactome.org link: R-HSA-193099