Reaction: 5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol
5Beta-cholesten-7alpha,12alpha,24(S)-triol-3-one and NADPH + H+ form 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol and NAPDP+. The reaction is catalyzed by 3alpha-hydroxysteroid dehydrogenase (AKR1C4), a cytosolic enzyme belonging to the aldo-keto reductase family (Dufort et al. 2001). Biochemical studies with rat proteins raise the possibility that other related enzymes may also carry out this reaction in vivo (Russell 2003).
Reaction - small molecule participants:
NADP+ [cytosol]
5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol [cytosol]
H+ [cytosol]
5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193781
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Reaction input - small molecules:
hydron
(24S)-7alpha,12alpha,24-trihydroxy-5beta-cholestan-3-one
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
(24S)-5beta-cholestane-3alpha,7alpha,12alpha,24-tetrol
Reactome.org link: R-HSA-193781