Reaction: CYP21A2 oxidises 17HPROG

- in pathway: Glucocorticoid biosynthesis
17-Hydroxyprogesterone, NADPH + H+, and O2 react to form 11-deoxycortisol, NADP+, and H2O. This reaction is catalyzed by CYP21A2 (steroid 21-hydroxylase) associated with the endoplasmic reticulum membrane.
Reaction - small molecule participants:
H2O [cytosol]
11-deoxycortisol [cytosol]
NADP+ [cytosol]
H+ [cytosol]
O2 [cytosol]
17aHPROG [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-193981

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Reaction input - small molecules:
hydron
ChEBI:15378
dioxygen
ChEBI:15379
17alpha-hydroxyprogesterone
ChEBI:17252
NADPH(4-)
ChEBI:57783
Reaction output - small molecules:
water
ChEBI:15377
11-deoxycortisol
ChEBI:28324
NADP(3-)
ChEBI:58349
Reactome.org link: R-HSA-193981