Reaction: CYP11B1 oxidises 11DCORT
- in pathway: Glucocorticoid biosynthesis
Cytochrome P450 11B1, mitochondrial (CYP11B1) usually hydroxylates 11-deoxycortisol (11DCORT) to form cortisol (CORT). CYP11B1 is associated with the inner mitochondrial membrane. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor, melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
CORT [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
11DCORT [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
NADP+ [mitochondrial matrix]
CORT [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
11DCORT [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-193997
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Reaction input - small molecules:
dioxygen
11-deoxycortisol
hydron
NADPH
dioxygen
11-deoxycortisol
hydron
NADPH
Reaction output - small molecules:
NADP(+)
cortisol
water
NADP(+)
cortisol
water
Reactome.org link: R-HSA-193997