Reaction: CYP11B2 oxidises 11DCORST to CORST
- in pathway: Mineralocorticoid biosynthesis
Cytochrome P450 11B2, mitochondrial (CYP11B2 aka aldosterone hydroxylase) is an enzyme necessary for aldosterone biosynthesis via corticosterone (CORST) and 18-hydroxycorticosterone (18HCORST). The 11-beta oxidation of 11-deoxycorticosterone (11DCORST) leads to corticosterone (CORST) and 18-hydroxylation of this leads to 18-hydroxycorticosterone (18HCORST). 18-oxidation of 18HCORST yields aldosterone.
Reaction - small molecule participants:
NADP+ [mitochondrial matrix]
CORST [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
11DCORST [mitochondrial matrix]
NADPH [mitochondrial matrix]
NADP+ [mitochondrial matrix]
CORST [mitochondrial matrix]
H2O [mitochondrial matrix]
O2 [mitochondrial matrix]
H+ [mitochondrial matrix]
11DCORST [mitochondrial matrix]
NADPH [mitochondrial matrix]
Reactome.org reaction link: R-HSA-194017
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Reaction input - small molecules:
dioxygen
hydron
11-deoxycorticosterone
NADPH
dioxygen
hydron
11-deoxycorticosterone
NADPH
Reaction output - small molecules:
NADP(+)
corticosterone
water
NADP(+)
corticosterone
water
Reactome.org link: R-HSA-194017