Reaction: Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol
- in pathway: Cholesterol biosynthesis via desmosterol
Cholesta-5,7,24-trien-3beta-ol and NADPH + H+ react to form desmosterol and NADP+. This reaction is catalyzed by DHCR7, associated with the endoplasmic reticulum membrane. The biochemical details of the reaction are inferred from those of the reaction catalyzed by the well-studied rat enzyme (Bae et al. 1999).
Reaction - small molecule participants:
NADP+ [cytosol]
DESMOL [endoplasmic reticulum membrane]
H+ [cytosol]
7dhDESOL [endoplasmic reticulum membrane]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-196402
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Reaction input - small molecules:
hydron
7-dehydrodesmosterol
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
desmosterol
Reactome.org link: R-HSA-196402