Reaction: Reduction of desmosterol to cholesterol
- in pathway: Cholesterol biosynthesis via desmosterol
Desmosterol is reduced by NADPH + H+ to form cholesterol and NADP+, catalyzed by DHCR24 associated with the endoplasmic reticulum membrane.
Reaction - small molecule participants:
CHOL [endoplasmic reticulum membrane]
NADP+ [cytosol]
H+ [cytosol]
DESMOL [endoplasmic reticulum membrane]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-196417
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Reaction input - small molecules:
hydron
desmosterol
NADPH(4-)
Reaction output - small molecules:
cholesterol
NADP(3-)
Reactome.org link: R-HSA-196417