Reaction: DHFR2 reduces FOLA to DHF
- in pathway: Metabolism of folate and pterines
Dihydrofolate reductase 2 (DHFR2) catalyzes the reduction of folate (FOLA) to dihydrofolate (DHF) (Chen et al. 1984).
Reaction - small molecule participants:
NADP+ [cytosol]
DHF [cytosol]
FOLA [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-197963
======
Reaction input - small molecules:
folic acid
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
dihydrofolate(2-)
Reactome.org link: R-HSA-197963