Reaction: SLC25A11 exchanges malate and alpha-ketoglutarate (2-oxoglutarate) across the inner mitochondrial membrane
- in pathway: Gluconeogenesis
The SLC25A11 transport protein in the inner mitochondrial membrane mediates the reversible exchange of mitochondrial malate (MAL) and cytosolic alpha-ketoglutarate (2OG, 2-oxoglutarate). Qualitative evidence for this process comes from studies of the human protein (Kabe et al. 2006); kinetic details are inferred from studies of rat mitochondria under conditions in which only the one transport protein appears to be active (Sluse et al. 1973). The dimeric state of the transport protein is inferred from studies of its bovine homologue (Bisaccia et al. 1996).
Reaction - small molecule participants:
2OG [mitochondrial matrix]
MAL [cytosol]
2OG [cytosol]
MAL [mitochondrial matrix]
Reactome.org reaction link: R-HSA-198440
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Reaction input - small molecules:
2-oxoglutarate(2-)
(S)-malate(2-)
Reaction output - small molecules:
2-oxoglutarate(2-)
(S)-malate(2-)
Reactome.org link: R-HSA-198440