Reaction: GSTO dimers reduce DeHA to AscH-
- in pathway: Vitamin C (ascorbate) metabolism
Cytosolic omega class glutathione transferases (GSTO1 and GSTO2) catalyze the reaction of dehydroascorbate (DeHA) and glutathione (GSH) to form ascorbate (AscH-) and oxidized glutathione (GSSG). The GSTO enzymes occur as homodimers (Board et al. 2000), and while both have dehydroascorbate reductase activity in vitro, that of GSTO2 is much greater than that of GSTO1 (Schmuck et al. 2005). Polymorphisms affecting the activities of the two enzymes have been described (Whitbread et al. 2005).
Reaction - small molecule participants:
AscH- [cytosol]
GSSG [cytosol]
GSH [cytosol]
DeHA [cytosol]
Reactome.org reaction link: R-HSA-198813
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Reaction input - small molecules:
glutathionate(1-)
L-dehydroascorbate
Reaction output - small molecules:
L-ascorbate
glutathione disulfide(2-)
Reactome.org link: R-HSA-198813