Reaction: 5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine
- in pathway: Metabolism of folate and pterines
Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and glycine to form tetrahydrofolate polyglutamate (THF polyglutamate) and serine. The active form of the enzyme is a tetramer (Renwick et al. 1998).
Reaction - small molecule participants:
L-Ser [cytosol]
THFPG [cytosol]
Gly [cytosol]
5,10-methylene-THFPG [cytosol]
Reactome.org reaction link: R-HSA-200651
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Reaction input - small molecules:
glycine zwitterion
5,10-methylenetetrahydrofolate polyglutamate macromolecule
Reaction output - small molecules:
L-serine zwitterion
tetrahydrofolyl-poly(glutamic acid) macromolecule
Reactome.org link: R-HSA-200651