Meta-Biol : Molecules : 5,10-methylenetetrahydrofolate polyglutamate macromolecule

Molecule: 5,10-methylenetetrahydrofolate polyglutamate macromolecule

An ionic macromolecule consisting of (6R)-5,10-methylenetetrahydrofolate(2-) with an arbitrary number of glutamate residues attached as a polypeptide to the single existent one.

Synonyms for 5,10-methylenetetrahydrofolate polyglutamate macromolecule :

5,10-methylenetetrahydrofolate polyglutamate

Molecular Formula: (C5H6NO3)n.C15H15N6O3

Molecular wt: g/mole

Charge: -2

SMILES:

InChIKey:

CHEBI:60473

Sample reactions for this molecule:

5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+

5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine

MTHFR dimer reduces 5,10-methylene-THFPG to 5-methyl-THFPG

MTHFD1 dimer dehydrogenates 5,10-methenyl-THFPG to 5,10-methylene-THFPG

SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG