Reaction: SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG
- in pathway: Metabolism of folate and pterines
Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of tetrahydrofolate polyglutamate (THF polyglutamate) and serine to form 5,10-methyleneTHF polyglutamate and glycine. The active form of the enzyme is a tetramer (Renwick et al. 1998). In the body, this reaction is a major source of 5,10-methyleneTHF, which in turn is a critical precursor in the synthesis of dTMP.
Reaction - small molecule participants:
Gly [cytosol]
5,10-methylene-THFPG [cytosol]
L-Ser [cytosol]
THFPG [cytosol]
Reactome.org reaction link: R-HSA-200735
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Reaction input - small molecules:
L-serine zwitterion
tetrahydrofolyl-poly(glutamic acid) macromolecule
Reaction output - small molecules:
glycine zwitterion
5,10-methylenetetrahydrofolate polyglutamate macromolecule
Reactome.org link: R-HSA-200735