Reaction: MTHFD1 dimer transforms 10-formyl-THFPG to 5,10-methenyl-THFPG
- in pathway: Metabolism of folate and pterines
The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 10-formylTHF polyglutamate to form 5,10-methenylTHF polyglutamate and H2O. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).
Reaction - small molecule participants:
H2O [cytosol]
5,10-methenyl-THFPG [cytosol]
10-formyl-THFPG [cytosol]
Reactome.org reaction link: R-HSA-200661
======
Reaction input - small molecules:
10-formyltetrahydrofolyl polyglutamate macromolecule
Reaction output - small molecules:
water
5,10-methenyltetrahydrofolate polyglutamate macromolecule
Reactome.org link: R-HSA-200661