Reaction: SLC25A32 transports THF from cytosol to mitochondrial matrix
- in pathway: Metabolism of folate and pterines
SLC25A32 protein in the inner mitochondrial membrane mediates the reversible transport of tetrahydrofolate between the cytosol and the mitochondrial matrix. Retention of tetrahydrofolate within the mitochondrial matrix is dependent on mitochondrial polyglutamate addition (Titus and Moran 2000; Chen et al. 1996).
Reaction - small molecule participants:
THF [mitochondrial matrix]
THF [cytosol]
Reactome.org reaction link: R-HSA-200680
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Reaction input - small molecules:
(6S)-5,6,7,8-tetrahydrofolate(2-)
Reaction output - small molecules:
(6S)-5,6,7,8-tetrahydrofolic acid
Reactome.org link: R-HSA-200680