Reaction: eNOS synthesizes NO
- in pathway: eNOS activation
Nitric oxide (NO) is produced from L-arginine by the family of nitric oxide synthases (NOS) enzymes, forming the free radical NO and citrulline as byproduct. The cofactor tetrahydrobiopterin (BH4) is an essential requirement for the delivery of an electron to the intermediate in the catalytic cycle of NOS.
Reaction - small molecule participants:
NO [cytosol]
NADP+ [cytosol]
L-Cit [cytosol]
L-Arg [cytosol]
O2 [cytosol]
NADPH [cytosol]
NO [cytosol]
NADP+ [cytosol]
L-Cit [cytosol]
L-Arg [cytosol]
O2 [cytosol]
NADPH [cytosol]
NO [cytosol]
NADP+ [cytosol]
L-Cit [cytosol]
L-Arg [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-202127
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Reaction input - small molecules:
L-argininium(1+)
dioxygen
NADPH(4-)
L-argininium(1+)
dioxygen
NADPH(4-)
L-argininium(1+)
dioxygen
NADPH(4-)
Reaction output - small molecules:
nitric oxide
NADP(3-)
L-citrulline zwitterion
nitric oxide
NADP(3-)
L-citrulline zwitterion
nitric oxide
NADP(3-)
L-citrulline zwitterion
Reactome.org link: R-HSA-202127