Reaction: Elongation of arachidonyl-CoA to docosatetraenoyl-CoA
- in pathway: Linoleic acid (LA) metabolism
Arachidonyl-CoA undergoes a two-carbon chain elongation on the carboxyl end to form docosatetraenoyl-CoA (DTA-CoA/Adrenic acid/7,10,13,16-docosatetraenoic acid (7,10,13,16-22:4(n-6)). This reaction is catalyzed by the enzymes ELOVL5 or ELOVL2. Malanoyl-CoA provides the additional two carbons required for elongation. Docosatetraenoyl-CoA is further metabolized by cyclooxygenases (COX), lipoxygenases (LO) and cytochrome P450s (CYP450s) to dihomo (DH) eicosanoids (Kopf et al. 2010, Leonard et al. 2004).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
CoA-SH [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
DTA-CoA [endoplasmic reticulum lumen]
Malonyl-CoA [endoplasmic reticulum lumen]
AA-CoA [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046083
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Reaction input - small molecules:
malonyl-CoA(5-)
arachidonoyl-CoA(4-)
NADPH
Reaction output - small molecules:
water
coenzyme A(4-)
carbon dioxide
(7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA
Reactome.org link: R-HSA-2046083