Reaction: Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
SDA-CoA (6,9,12,15-18:4(n-3)) is rapidly elongated by two carbon atoms to 8,11,14,17-eicosatetraenoyl-CoA (8,11,14,17-20:4(n-3), ETA-CoA). The NADPH-consuming enzyme long-chain fatty acyl elongase (ELOVL5) mediates this reaction which and adds malonyl-CoA to the SDA-CoA and releases carbon dioxide and free CoA (Leonard et al. 2004).
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
ETA-CoA [endoplasmic reticulum lumen]
CoA-SH [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
Malonyl-CoA [endoplasmic reticulum lumen]
SDA-CoA [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046088
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Reaction input - small molecules:
malonyl-CoA(5-)
(6Z,9Z,12Z,15Z)-octadecatetraenoyl-CoA
NADPH
Reaction output - small molecules:
water
NADP(+)
(8Z,11Z,14Z,17Z)-icosatetraenoyl-CoA
coenzyme A(4-)
carbon dioxide
Reactome.org link: R-HSA-2046088