Reaction: Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA
- in pathway: alpha-linolenic acid (ALA) metabolism
Docosapentaenoyl-CoA is elongated to tetracosapentaenoyl-CoA (9,12,15,18,21-24:5(n-3)) by the enzyme ELOVL2.
Reaction - small molecule participants:
H2O [endoplasmic reticulum lumen]
TPA-CoA [endoplasmic reticulum lumen]
NADP+ [endoplasmic reticulum lumen]
CoA-SH [endoplasmic reticulum lumen]
CO2 [endoplasmic reticulum lumen]
Malonyl-CoA [endoplasmic reticulum lumen]
DPA-CoA [endoplasmic reticulum lumen]
NADPH [endoplasmic reticulum lumen]
Reactome.org reaction link: R-HSA-2046090
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Reaction input - small molecules:
malonyl-CoA(5-)
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA
NADPH
Reaction output - small molecules:
water
(9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA
NADP(+)
coenzyme A(4-)
carbon dioxide
Reactome.org link: R-HSA-2046090