Reaction: p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor
- in pathway: NRAGE signals death through JNK
Following NGF binding, p75NTR activates the RAC (Ras-related C3 botulinum toxin substrate) GTPase.
Reaction - small molecule participants:
GDP [cytosol]
GTP [cytosol]
Reactome.org reaction link: R-HSA-205039
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Reaction input - small molecules:
GTP(4-)
Reaction output - small molecules:
GDP(3-)
Reactome.org link: R-HSA-205039