Reaction: CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3
PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).)
Reaction - small molecule participants:
PI(3,4,5)P3 [plasma membrane]
PI(4,5)P2 [plasma membrane]
Reactome.org reaction link: R-HSA-2076220
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Reaction input - small molecules:
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate(5-)
Reaction output - small molecules:
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate(7-)
Reactome.org link: R-HSA-2076220