Reaction: PPM1A dephosphorylates nuclear SMAD2/3
- in pathway: Downregulation of SMAD2/3:SMAD4 transcriptional activity
In the nucleus, protein type 2C phosphatase, PPM1A, dephosphorylates SMAD2 and SMAD3, resulting in dissociation of SMAD2/3:SMAD4 heterotrimeric complexes.
Reaction - small molecule participants:
Pi [nucleoplasm]
H2O [nucleoplasm]
Reactome.org reaction link: R-HSA-209055
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Reaction input - small molecules:
water
Reaction output - small molecules:
hydrogenphosphate
Reactome.org link: R-HSA-209055