Reaction: 25(OH)D translocates from lysosomal lumen to cytosol
- in pathway: Vitamin D (calciferol) metabolism
Once out of the lysosome, 25-hydroxyvitamin D (calcidiol, 25(OH)D) translocates to the mitochondion where it is made available to the mitochondrial membrane-resident protein CYP27B1 for further hydroxylation. The mechanism of mitochondrial targeting is unknown but may involve some kind of intracellular vitamin D binding protein (IDBP). IDBPs are related to the hsc-70 family of heat shock proteins and may function to localise vitamin D metabolites to specific areas. No human IDBP has yet been characterised (Radons 2016).
Reaction - small molecule participants:
25(OH)D [cytosol]
25(OH)D [lysosomal lumen]
Reactome.org reaction link: R-HSA-209766
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Reaction input - small molecules:
calcidiol
Reaction output - small molecules:
calcidiol
Reactome.org link: R-HSA-209766