Reaction: Thyroxine is deiodinated to triiodothyronine
- in pathway: Regulation of thyroid hormone activity
Iodothyronine deiodinases 1 and 2 (DIO1/2) are the vertebrate enzymes responsible for the deiodination of the prohormone thyroxine (T4; 3,5,3',5'-tetraiodothyronine) into the biologically active hormone T3 (3,5,3'-triiodothyronine). DIO1/2 activity is critical for appropriate T3 levels in the brain during development.
Reaction - small molecule participants:
I- [cytosol]
T3 [cytosol]
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
T4 [cytosol]
Reactome.org reaction link: R-HSA-209772
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Reaction input - small molecules:
hydron
NADPH(4-)
L-thyroxine
Reaction output - small molecules:
iodide
3,3',5'-triiodothyronine
NADP(3-)
Reactome.org link: R-HSA-209772