Reaction: Methylation of N-acetyl-5-HT to form melatonin
- in pathway: Serotonin and melatonin biosynthesis
Hydroxyindole-O-methyltransferase (HIOMT) catalyzes the last step in the synthesis of melatonin. Melatonin is synthesized and released by the pineal gland and is thought to control circadian rhythms. HIOMT has 3 isoforms and utilizes S-adenosyl-L-methionine (SAM) as the methyl donor in the conversion of N-acetyl-5HT to melatonin.
Reaction - small molecule participants:
MLT [cytosol]
H+ [cytosol]
AdoHcy [cytosol]
AdoMet [cytosol]
Ac5HT [cytosol]
Reactome.org reaction link: R-HSA-209821
======
Reaction input - small molecules:
S-adenosyl-L-methionine zwitterion
N-acetylserotonin
Reaction output - small molecules:
melatonin
hydron
S-adenosyl-L-homocysteine zwitterion
Reactome.org link: R-HSA-209821