Reaction: Noradrenaline is converted to adrenaline
- in pathway: Catecholamine biosynthesis
Phenylethanolamine N-methyltransferase (PNMT) is the terminal enzyme in catecholamine biosynthesis. It performs transmethylation of noradrenaline to adrenaline using S-adenosyl L-methionine (SAM) as the methyl donor.
Reaction - small molecule participants:
H+ [cytosol]
AdoHcy [cytosol]
ADR [cytosol]
NAd [cytosol]
AdoMet [cytosol]
Reactome.org reaction link: R-HSA-209903
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Reaction input - small molecules:
(R)-noradrenaline(1+)
S-adenosyl-L-methionine zwitterion
Reaction output - small molecules:
hydron
S-adenosyl-L-homocysteine zwitterion
(R)-adrenaline(1+)
Reactome.org link: R-HSA-209903