Reaction: CYP4F2, 4F3 20-hydroxylate LTB4
- in pathway: Eicosanoids
Leukotriene B4 (LTB4) is formed from arachidonic acid and is a potent inflammatory mediator. LTB4's activity is terminated by formation of its omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20OH-LTB4), catalysed by CYP4F2 primarily in human liver (Jin et al. 1998) and also by CYP4F3 (Kikuta et al. 1998).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
20OH-LTB4 [cytosol]
LTB4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
H2O [cytosol]
NADP+ [cytosol]
20OH-LTB4 [cytosol]
LTB4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-211873
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Reaction input - small molecules:
leukotriene B4
hydron
dioxygen
NADPH(4-)
leukotriene B4
hydron
dioxygen
NADPH(4-)
Reaction output - small molecules:
water
NADP(3-)
20-hydroxy-leukotriene B4
water
NADP(3-)
20-hydroxy-leukotriene B4
Reactome.org link: R-HSA-211873