Reaction: PGH2 is reduced to PGF2a by AKR1C3
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is responsible for the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Suzuki-Yamamoto et al. 1999, Komoto et al. 2004, Komoto et al. 2006). There is an additional way of achieving this reaction involving the prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TRX).
Reaction - small molecule participants:
NADP+ [cytosol]
PGF2a [cytosol]
H+ [cytosol]
PGH2 [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161549
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Reaction input - small molecules:
hydron
prostaglandin H2
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
prostaglandin F2alpha
Reactome.org link: R-HSA-2161549