Reaction: LTB4 is oxidised to 12-oxoLTB4 by PTGR1
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eicosanoids by catalysing the oxidation of leukotriene B4 (LTB4) to form 12-oxo-Leukotriene B4 (12-oxoLTB4) aka 12-Keto-LTB4. The gene was originally cloned as leukotriene B4 12-hydroxydehydrogenase (LTB4DH) but was later discovered to have dual functionality as a prostaglandin reductase (Yokomizo et al. 1996). This reaction has been inferred from a reaction in pigs (Yokomizo et al. 1993, Ensor et al. 1998).
Reaction - small molecule participants:
H+ [cytosol]
12-oxoLTB4 [cytosol]
NADPH [cytosol]
LTB4 [cytosol]
NADP+ [cytosol]
Reactome.org reaction link: R-HSA-2161567
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Reaction input - small molecules:
leukotriene B4
NADP(3-)
Reaction output - small molecules:
hydron
12-dehydro-leukotriene B4
NADPH(4-)
Reactome.org link: R-HSA-2161567