Reaction: PGD2 is reduced to 11-epi-PGF2a by AKRIC3
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is the enzyme involved in NADPH-dependent prostaglandin D2 11-keto reductase activity of reducing prostaglandin D2 (PGD2) to 11-epi-Prostaglandin F2alpha (11-epi-PGF2a) (Liston & Roberts 1985, Koda et al. 2004).
Reaction - small molecule participants:
NADP+ [cytosol]
11epi-PGF2a [cytosol]
H+ [cytosol]
NADPH [cytosol]
PGD2 [cytosol]
Reactome.org reaction link: R-HSA-2161614
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Reaction input - small molecules:
hydron
NADPH(4-)
prostaglandin D2
Reaction output - small molecules:
NADP(3-)
11-epi-prostaglandin F2alpha
Reactome.org link: R-HSA-2161614