Reaction: PGE2 is dehydrated to PGA2
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Cyclopentenone prostaglandins comprise a family of molecules that are formed by dehydration of hydroxyl moieties in prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). Dehydration of PGE2 leads to prostaglandin A2 (PGA2) (Hamberg & Samuelsson B 1966, Amin 1989).
Reaction - small molecule participants:
PGA2 [cytosol]
H2O [cytosol]
PGE2 [cytosol]
Reactome.org reaction link: R-HSA-2161659
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Reaction input - small molecules:
prostaglandin E2
Reaction output - small molecules:
prostaglandin A2
water
Reactome.org link: R-HSA-2161659