Reaction: PGH2 is isomerised to PGE2 by PTGES
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Prostaglandin E synthase (PTGES) requires glutathione (GSH) as an essential cofactor for its enzymatic activity, and together they isomerise prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) (Jegerschold et al. 2008). After PGH2 has been produced by the prostaglandin G/H synthases (PTGS1 and 2) on the lumenal side of the endoplasmic reticulum, it diffuses through the membrane to the active site of PTGES located on the cytoplasmic side.
Reaction - small molecule participants:
PGE2 [cytosol]
PGH2 [cytosol]
Reactome.org reaction link: R-HSA-2161660
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Reaction input - small molecules:
prostaglandin H2
Reaction output - small molecules:
prostaglandin E2
Reactome.org link: R-HSA-2161660