Reaction: 15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1
- in pathway: Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Prostaglandin reductase 2 (PTGR2) is a 13-prostaglandin reductase which metabolises eicosanoids by catalysing NADH/NADPH-dependant double bond reduction in 15-keto-prostaglandin E2 (15k-PGE2) and F2alpha (15k-PGF2a) to produce 13,14-dihydro-15-keto-prostaglandin E2 (dhk-PGE2) and F2alpha (dhk-PGF2a) respectively (Wu et al. 2008). This has been inferred from the reaction event in mice involving prostaglandin reductase 2 (Ptgr2) (Chou et al. 2007).
Reaction - small molecule participants:
NADP+ [cytosol]
H+ [cytosol]
NADPH [cytosol]
Reactome.org reaction link: R-HSA-2161692
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Reaction input - small molecules:
hydron
NADPH(4-)
Reaction output - small molecules:
NADP(3-)
Reactome.org link: R-HSA-2161692