Reaction: 20oh-LTB4 is oxidised to 20cho-LTB4 by CYP4F2/4F3
- in pathway: Synthesis of Leukotrienes (LT) and Eoxins (EX)
The cytochrome P450s 4F2 (CYP4F2) and F3 (CYP4F3) oxidise the omega hydroxylated metabolite, 20-hydroxyleukotriene B4 (20oh-LTB4) to form 20-aldehyde leukotriene B4 (20cho-LTB4) (Soberman et al. 1988).
Reaction - small molecule participants:
H2O [cytosol]
NADP+ [cytosol]
20cho-LTB4 [cytosol]
H+ [cytosol]
O2 [cytosol]
NADPH [cytosol]
20OH-LTB4 [cytosol]
Reactome.org reaction link: R-HSA-2161745
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Reaction input - small molecules:
hydron
dioxygen
NADPH(4-)
20-hydroxy-leukotriene B4
Reaction output - small molecules:
water
NADP(3-)
20-oxoleukotriene B4
Reactome.org link: R-HSA-2161745