Reaction: 15S-HpETE is reduced to 15S-HETE by GPX1/2/4
- in pathway: Synthesis of 15-eicosatetraenoic acid derivatives
Glutathione peroxidases (GPXs) in human platelets (either GPX1, GPX2, or GPX4 are present in the cytosol) are involved in reducing 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) to 15S-hydroxyeicosatetraenoic acid (15S-HETE) (Hill et al. 1989).
Reaction - small molecule participants:
H2O [cytosol]
15S-HETE [cytosol]
GSSG [cytosol]
15S-HpETE [cytosol]
GSH [cytosol]
Reactome.org reaction link: R-HSA-2161791
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Reaction input - small molecules:
15(S)-HPETE
glutathionate(1-)
Reaction output - small molecules:
water
15(S)-HETE
glutathione disulfide(2-)
Reactome.org link: R-HSA-2161791